Saints Fall to 49ers 21-26 in Thrilling Contest
Saints Fall to 49ers 21-26 in Thrilling Contest
New Orleans, Week 2 NFL 2025 - The New Orleans Saints suffered a narrow 21-26 defeat to the San Francisco 49ers at Caesars Superdome. This electrifying game saw explosive plays from both teams, but the 49ers capitalized better to secure the victory.

The Saints started slowly, allowing the 49ers to take the lead with steady play from QB Mac Jones, who filled in for the injured Brock Purdy. Jones completed 26 of 39 passes, throwing 3 touchdowns. The Saints countered with an impressive performance from QB Spencer Rattler, who threw 3 TDs to Juwan Johnson, Rashid Shaheed, and Devaughn Vele. However, the Saints’ offense struggled to maintain momentum under pressure from the 49ers’ defense.
In the fourth quarter, the Saints mounted a comeback effort, highlighted by a 13-yard run from Alvin Kamara and a one-handed catch by Shaheed. Yet, a critical fumble by Rattler in the final moments dashed their hopes of a turnaround. The Saints’ defense shone with two sacks from Carl Granderson and a strip-sack by Chris Rumph II, but it wasn’t enough to stop the 49ers from adding points with two field goals.
Head Coach Kellen Moore admitted the team needs to improve consistency and reduce individual errors. This loss drops the Saints to 0-2, while the 49ers improve to 2-0. The defeat serves as a wake-up call for the Saints ahead of their matchup against the Seattle Seahawks next week. Caesars Superdome remained electric, but the Saints must regain their form to compete in the NFC.
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